Screening of collapsed mouse urinary bladders by optical matched filtering

The principles of optical matched filtering are applied to the problem of screening specimens of mouse urinary bladders that may exhibit hyperplasia or contain carcinomas resulting from the ingestion of controlled amounts of 2-acetylaminofluorene. The construction of the matched filter and the experimental procedure are optimized for a small group of specimens to the extent that thirteen of twenty-two normal specimens are correctly classified, and all fifteen of the abnormal specimens are correctly classified.