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Related Experiment Videos

Laetrile toxicity studies in dogs.

E S Schmidt, G W Newton, S M Sanders

    JAMA
    |March 6, 1978
    PubMed
    Summary

    Oral laetrile is highly toxic, especially when consumed with common foods. Studies show laetrile administration led to cyanide poisoning and neurological damage in dogs, with a high mortality rate.

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    Area of Science:

    • Toxicology
    • Veterinary Medicine
    • Nutritional Science

    Background:

    • Laetrile, a compound found in apricot kernels and almonds, has been explored for potential cancer treatments.
    • Concerns exist regarding the safety and efficacy of laetrile, particularly its potential for toxicity.

    Purpose of the Study:

    • To investigate the toxicity of oral laetrile when administered to dogs under various conditions.
    • To assess the potential for cyanide poisoning and neurological impairment resulting from laetrile consumption.

    Main Methods:

    • Dogs were administered oral laetrile and fresh, sweet almonds.
    • Doses were comparable to those prescribed for human cancer patients, ranging from equivalent to five times the human dose on a per square meter basis.
    • Animals were observed for signs of toxicity, including mortality and neurological deficits.

    Main Results:

    • Six out of ten dogs died from acute cyanide poisoning.
    • One dog recovered, while three exhibited varying degrees of neurological impairment, from ataxia to coma.
    • Laetrile demonstrated significant toxicity when ingested with common food items.

    Conclusions:

    • Oral laetrile is highly toxic and poses a significant risk of cyanide poisoning.
    • Increased availability of laetrile may lead to a rise in human cyanide poisoning cases.
    • Dietary interactions can exacerbate laetrile toxicity.

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