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Surface-modified upconverting microparticles and nanoparticles for use in click chemistries.

Heike S Mader¹, Martin Link, Daniela E Achatz

¹Institute of Analytical Chemistry, Chemo- and Biosensors, University of Regensburg,93040 Regensburg, Germany.

Chemistry (Weinheim an Der Bergstrasse, Germany)

|April 8, 2010

Summary

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Researchers developed a click chemistry method for modifying upconverting microparticles (UCmuPs) and nanoparticles (UCNPs). This enables versatile labeling for applications like imaging, biolabeling, and security encoding.

Area of Science:

Materials Science
Nanotechnology
Chemical Biology

Background:

Upconverting microparticles (UCmuPs) and nanoparticles (UCNPs) are valuable for various applications.
Surface modification is crucial for expanding the utility of these particles.
Click chemistry offers a robust and efficient platform for bioconjugation.

Purpose of the Study:

To develop a method for surface modification of UCmuPs and UCNPs to enable click chemistry.
To demonstrate the versatile labeling capabilities of modified particles using click reactions.
To explore potential applications in imaging, biolabeling, and security.

Main Methods:

Surface modification of UCmuPs and UCNPs using specific reagents, with or without tetraethoxysilane.
Application of click chemistry for labeling particles with fluorophores, maleinimido groups, and biotin.

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Characterization of labeled particles for their optical and binding properties.

Main Results:

Successfully modified the surface of both UCmuPs and UCNPs for click chemistry compatibility.
Demonstrated wavelength-dependent emission colors when labeled with fluorophores.
Achieved specific labeling for thiols and biotinylation for affinity-based studies.

Conclusions:

The developed click chemistry method provides a versatile platform for functionalizing UCmuPs and UCNPs.
Modified particles show potential for advanced applications in upconversion imaging, biolabeling, and security features.
This approach broadens the scope of UCMP and UCNP utilization in diverse scientific fields.