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Developmental changes in presynaptic Ca(2 +) clearance kinetics and synaptic plasticity in mouse Schaffer collateral

Chessa S Scullin¹, Michael C Wilson, L Donald Partridge

¹Department of Neurosciences, University of New Mexico, Albuquerque, NM, USA.

The European Journal of Neuroscience

|April 9, 2010

Summary

Neurotransmitter release relies on calcium dynamics. This study reveals how residual calcium ([Ca(2+)](res)) changes during early development, impacting neuronal plasticity and paired-pulse facilitation in rodent brains.

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Area of Science:

Neuroscience
Developmental Biology
Cellular Physiology

Background:

Presynaptic calcium (Ca2+) dynamics are crucial for neurotransmitter release and short-term plasticity.
Significant developmental changes occur in Ca2+ influx, buffering, and extrusion during the first postnatal month in neurons.
Newborn neurons exhibit minimal paired-pulse facilitation, unlike mature neurons.

Purpose of the Study:

To investigate developmental alterations in residual calcium ([Ca(2+)](res)) dynamics in presynaptic terminals.
To correlate changes in [Ca(2+)](res) with the maturation of short-term plasticity at Schaffer collateral to CA1 synapses.

Main Methods:

Measurement of [Ca(2+)](res) decay timecourse in acute hippocampal slices from rodents.
Application of single and paired orthodromic stimuli in the stratum radiatum.
Assessment of caffeine-sensitive basal Ca2+ stores and endoplasmic reticulum Ca2+ uptake inhibition.

Main Results:

Developmental shifts in the rise time and slow exponential decay of [Ca(2+)](res) were observed, with faster decay in adults.
Adult presynaptic terminals showed a larger and faster decay of [Ca(2+)](res) compared to newborns.
Younger mice (P6 and younger) had greater caffeine-sensitive basal Ca2+ stores than adults, with differential effects upon blocking endoplasmic reticulum Ca2+ uptake.

Conclusions:

[Ca(2+)](res) dynamics undergo gradual developmental transitions over the first postnatal weeks.
These developmental changes in calcium handling correlate with the emergence of adult-like short-term plasticity.
Understanding these calcium dynamics is key to comprehending neuronal maturation and synaptic function.