Related Experiment Video
Updated: Jun 14, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
Fc gamma receptor biology and systemic lupus erythematosus
Vojislav Jovanovic1, Xilei Dai, Yan Ting Lim
1Department of Microbiology, Life Sciences Institute Immunology Program, The Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore.
Abstract:
The maintenance of immune homeostasis and the regulation of pro-inflammatory responses that underlie autoimmune pathology require a coordinated interplay between cytokines, cellular receptors and downstream signaling pathways. The family of fragment crystallizable receptors for immunoglobulin G (IgG) (Fc gammaR) represents a good example of how controlling the simultaneous triggering of activatory and/or inhibitory receptors results in a balanced immune response. Fc gammaRs play a crucial role in linking the antibody-mediated recognition of pathogens, allergens or auto-antigens to the cellular arm of the immune response. In this review, we detail how dysfunction in Fc gammaR pathways is linked to the development of the autoimmune disease, systemic lupus erythematosus.
Related Concept Videos
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
The JAK-STAT Signaling Pathway
Receptor Downregulation in MVBs
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR activation may...
TGF - β Signaling Pathway
Inflammatory Bowel Disease III: Crohn's Disease
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
