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Identifying Transcription Factor Olig2 Genomic Binding Sites in Acutely Purified PDGFRα+ Cells by Low-cell Chromatin Immunoprecipitation Sequencing Analysis
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Efficient online transcription factor binding site adjustment by integrating transitive graph projection with MoRAine

Tobias Wittkop1, Sven Rahmann, Jan Baumbach

  • 1Genome Informatics, Bielefeld University, Bielefeld, Germany. Tobias.Wittkop@CeBiTec.Uni-Bielefeld.DE

Journal of Integrative Bioinformatics
|April 9, 2010
PubMed
Abstract

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Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form dimers that...