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Updated: Jun 14, 2026

An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions
Published on: March 22, 2018
Study of the triplet periodicity phase shifts in genes
Eugene V Korotkov1, Maria A Korotkova
1Bioinformatics laboratory, Centre of Bioengineering, Russian Academy of Sciences, Prospect 60-tya Oktyabrya 7/1, Moscow 117312, Russia. genekorotkov@gmail.com
Abstract:
The definition of a phase shift of triplet periodicity (TP) is introduced. The mathematical algorithm for detection of TP phase shift of nucleotide sequences has been developed. Gene sequences from Kegg-46 data bank were analyzed with a purpose of searching genes with a phase shift of TP. The presence of a phase shift of triplet periodicity has been shown for 318329 genes (approximately 10% from the number of genes in Kegg-46). We suppose that shifts of the TP phase may indicate the shifts of reading frame (RF) in genes. A relationship between the phase shifts of TP and the frame shifts in genes is discussed.
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