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Updated: Jun 14, 2026

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems
Published on: May 2, 2025
A randomized crossover investigation of pain at dressing change comparing 2 foam dressings
Kevin Y Woo1, Patricia M Coutts, Patricia Price
1Wound Healing Clinic, The New Women's College Hospital, Toronto, Ontario, Canada.
Introduction:
Pain at dressing change is the result of several factors including trauma and skin stripping caused by the repeated removal of adhesive dressings.
Goals:
To evaluate pain during dressing changes comparing a soft silicone foam dressing (Mepilex Border; Mölnlycke Health Care AB, Gothenburg, Sweden) with an adhesive hydrocellular polyurethane foam dressing (Allevyn Adhesive; Smith & Nephew, Hull, United Kingdom).
Methods:
In this randomized crossover study, subjects were randomized to 1 of the 2 foam dressings for the first 2 scheduled follow-up visits. At visit 3, local wound treatment was switched to the alternate dressing until the end of the study (visits 4 and 5). Pain was measured with a visual analog scale and the Short-Form McGill Pain Questionnaire. The characteristics of the wound and the occurrence of adverse events were documented at each scheduled visit.
Results:
A total of 32 patients entered into the study, and 26 patients completed all 5 follow-up study visits. Results indicated lower levels of pain at dressing removal and less periwound maceration in patients who were randomized to the silicone dressings.
Conclusions:
The results of this study indicate that soft silicone dressing is associated with less pain before and during dressing changes along with decreased periwound maceration.
Related Concept Videos
Crossover Experiments
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.
Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs

