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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
The Th17 immune response in renal inflammation
Jan-Eric Turner1, Hans-Joachim Paust, Oliver M Steinmetz
1III Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, 20246 Hamburg, Germany.
Kidney International
|April 9, 2010
Summary
The T-helper 17 (Th17) immune response, driven by interleukin-17 (IL-17), is now understood to play a key role in autoimmune diseases. This review focuses on the Th17 cell
Area of Science:
- Immunology
- Cell Biology
- Pathology
Background:
- T-helper 17 (Th17) cells represent a distinct T-helper cell lineage.
- The Th17 immune response, mediated by cytokines like IL-17, is implicated in tissue injury and autoimmune diseases.
- Recent research suggests a significant role for Th17 cells in renal inflammatory diseases.
Purpose of the Study:
- To review the general characteristics of Th17 cells.
- To discuss the potential role of Th17 immune responses in human and experimental renal inflammation.
- To focus on the contribution of Th17 cells to glomerulonephritis.
Main Methods:
- Literature review of studies on Th17 cells and renal inflammation.
- Analysis of data from human and mouse models of autoimmune and renal diseases.
- Synthesis of current knowledge on the IL-23/Th17 axis in kidney injury.
Main Results:
- Th17 cells and their associated cytokines (IL-17, IL-17F, IL-21, IL-22, IL-9) promote inflammation and tissue damage.
- Leukocyte infiltration, particularly neutrophils, is enhanced by Th17-mediated inflammation.
- Evidence supports the involvement of IL-17 and the IL-23/Th17 axis in glomerulonephritis pathogenesis.
Conclusions:
- The Th17 immune response is a critical driver of tissue injury in various autoimmune conditions, including renal diseases.
- Understanding the Th17 pathway is crucial for developing targeted therapies for inflammatory kidney diseases like glomerulonephritis.
- Further research is warranted to elucidate the precise mechanisms of Th17-mediated renal injury.
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