Related Experiment Video
Updated: Jun 14, 2026

08:14
Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
Published on: September 29, 2015
Platelet-rich-fibrin: A novel root coverage approach
K Anilkumar1, A Geetha, Umasudhakar
1Lecturer, Department of Periodontics, Meenakshi Ammal Dental College, Madhuravoyal, Chennai - 600 095, India.
Journal of Indian Society of Periodontology
|April 9, 2010
Summary
Platelet-rich fibrin (PRF) membrane aids in root coverage for gingival recession, promoting periodontal regeneration. This technique, using a laterally displaced flap, offers a predictable solution for esthetic concerns.
Area of Science:
- Periodontal Medicine
- Regenerative Dentistry
- Biomaterials in Oral Surgery
Background:
- Gingival recession presents a significant therapeutic challenge, driven by rising esthetic demands.
- Periodontal regenerative surgery aims for complete wound healing and regeneration of the periodontal unit.
- Platelet-rich plasma (PRP) contains concentrated growth factors that promote wound healing and tissue regeneration.
Observation:
- This study investigates the application of platelet-rich fibrin (PRF) membrane for root coverage.
- The procedure focused on the labial surfaces of mandibular anterior teeth.
- A laterally displaced flap technique was employed, incorporating the PRF membrane at the recipient site.
Findings:
- The use of PRF membrane in conjunction with a laterally displaced flap technique facilitated root coverage.
- The application demonstrated successful integration of the PRF membrane for periodontal regeneration.
- This approach shows promise for achieving predictable esthetic outcomes in treating gingival recession.
Implications:
- PRF membrane represents a valuable biomaterial in periodontal regenerative surgery.
- This technique offers a potentially effective method for addressing cosmetic concerns related to gingival recession.
- Further research can explore the long-term efficacy and broader applications of PRF in dentistry.
Related Concept Videos
Clot Retraction and Fibrinolysis
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
Formation of the Platelet Plug
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Introduction to Hemostasis
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...
Venous Thrombosis III: Interprofessional Care
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...