Related Experiment Video
Updated: Jun 14, 2026
Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
Published on: October 21, 2022
[Unusual stromal corneal deposits]
1Augenklinik, Heinrich-Heine-Universität Düsseldorf, Moorenstrasse 5, 40225, Düsseldorf, Deutschland. DFinis@web.de
A 70-year-old woman with vision loss and glare sensitivity was diagnosed with IgG-kappa myeloma. Chemotherapy successfully treated the systemic disease and improved her vision.
Area of Science:
- Ophthalmology
- Hematology
- Oncology
Background:
- Corneal deposits can indicate underlying systemic disease.
- Myeloma-associated ocular manifestations are rare but significant.
Observation:
- A patient presented with progressive vision deterioration and glare.
- Slit-lamp examination revealed atypical stromal corneal deposits.
Findings:
- Diagnostic workup, including protein electrophoresis and bone marrow aspiration, confirmed IgG-kappa myeloma.
- The corneal deposits were associated with the underlying plasma cell disorder.
Implications:
- This case highlights the importance of considering systemic conditions in atypical corneal findings.
- Early diagnosis and treatment of myeloma can prevent irreversible vision loss.
- Ophthalmologists should be aware of potential ocular manifestations of plasma cell dyscrasias.
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