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[Optic neuropathy in Schmidt-Carpenter syndrome].

P C Horn¹, J Harder, C P Lohmann

¹Klinikum rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, 81675, München, Germany. peter.horn@mytum.de

Der Ophthalmologe : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft

|April 9, 2010

Summary

Systemic hypotension worsens normal pressure glaucoma. Treating this endocrine disorder by managing blood pressure and intraocular pressure may slow glaucoma progression.

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Area of Science:

Endocrinology
Ophthalmology
Glaucoma Research

Background:

Systemic hypotension is a known risk factor for normal pressure glaucoma (NPG) progression.
Glaucoma is characterized by optic nerve damage and visual field loss.
Endocrine disorders can impact multiple organ systems, including the eyes.

Observation:

A female patient presented with glaucomatous disc changes despite normal intraocular pressure measurements.
The patient had a history of adrenal, thyroid, and pancreatic islet cell failure, indicative of Schmidt-Carpenter syndrome.
This case highlights a potential link between Schmidt-Carpenter syndrome and ocular pathology.

Findings:

Schmidt-Carpenter syndrome, leading to systemic hypotension, may underlie the observed glaucomatous changes.
The patient's ocular condition presented an opportunity to study the effects of managing nocturnal blood pressure alongside intraocular pressure.
This clinical scenario suggests a novel therapeutic approach for NPG in the context of specific endocrine failures.

Implications:

Managing systemic blood pressure, particularly nocturnal levels, could be a crucial adjunct therapy for NPG in patients with Schmidt-Carpenter syndrome.
This case broadens the understanding of NPG etiology and management strategies.
Further research is warranted to explore the relationship between endocrine dysfunction and glaucoma progression.