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Related Experiment Video

Updated: Jun 14, 2026

Combining Analysis of DNA in a Crude Virion Extraction with the Analysis of RNA from Infected Leaves to Discover New Virus Genomes

Combining Analysis of DNA in a Crude Virion Extraction with the Analysis of RNA from Infected Leaves to Discover New Virus Genomes

Published on: July 27, 2018

The caliciviruses.

Umesh Katpally¹, Thomas J Smith

¹Donald Danforth Plant Science Center, Saint Louis, MO, 63132, USA.

Current Topics in Microbiology and Immunology

|April 9, 2010

Summary

This summary is machine-generated.

Caliciviruses cause major non-bacterial gastroenteritis outbreaks. Advances in protein expression and a mouse norovirus model are improving understanding of calicivirus structure and host immune responses.

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Reverse Genetics Mediated Recovery of Infectious Murine Norovirus

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Published on: June 24, 2012

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Last Updated: Jun 14, 2026

Combining Analysis of DNA in a Crude Virion Extraction with the Analysis of RNA from Infected Leaves to Discover New Virus Genomes

Combining Analysis of DNA in a Crude Virion Extraction with the Analysis of RNA from Infected Leaves to Discover New Virus Genomes

Published on: July 27, 2018

Reverse Genetics Mediated Recovery of Infectious Murine Norovirus

Reverse Genetics Mediated Recovery of Infectious Murine Norovirus

Published on: June 24, 2012

Area of Science:

Virology
Immunology
Gastroenterology

Background:

Caliciviruses are a primary cause of non-bacterial gastroenteritis.
Historically, research was limited by the absence of suitable animal models and tissue culture systems.
These viruses are highly infectious with rapid, severe symptom onset.

Purpose of the Study:

To review current understanding of caliciviruses.
To highlight recent advances in studying calicivirus structure and host immune response.

Main Methods:

Utilizing advances in protein expression systems.
Employing a newly developed mouse norovirus animal model.

Main Results:

Recent progress has significantly enhanced the understanding of calicivirus structure.
New insights into host immune responses to caliciviruses have been gained.

Conclusions:

The development of a mouse norovirus model and improved protein expression systems have overcome previous research limitations.
There has been a rapid advancement in understanding caliciviruses, particularly their structure and host interactions.