Related Experiment Video
Updated: Jun 14, 2026

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information
Published on: July 1, 2020
Evaluating between-pathway models with expression data
B J Hescott1, M D M Leiserson, L J Cowen
1Department of Computer Science, Tufts University, Medford, Massachusetts 02155, USA. hescott@cs.tufts.edu
Abstract:
Between-pathway models (BPMs) are network motifs consisting of pairs of putative redundant pathways. In this article, we show how adding another source of high-throughput data--microarray gene expression data from knockout experiments--allows us to identify a compensatory functional relationship between genes from the two BPM pathways. We evaluate the quality of the BPMs from four different studies, and we describe how our methods might be extended to refine pathways.
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