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A 3D Organotypic Melanoma Spheroid Skin Model

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Patterns in naevoid skin disease: development, disease and modelling.

Stephen J Gilmore¹

¹Dermatology Research Centre, The University of Queensland, School of Medicine, Princess Alexandra Hospital, Brisbane, Australia. s.gilmore1@uq.edu.au

Experimental Dermatology

|April 10, 2010

Summary

The cause of pattern formation in human naevoid skin disease is unknown. Self-organization principles offer a comprehensive explanation, potentially revealing insights into early human embryogenesis.

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Area of Science:

Developmental biology
Dermatology
Genetics

Background:

The etiology of pattern formation in human naevoid skin disease is currently unknown.
Existing theories focusing on passive clonal trafficking during embryogenesis are likely incomplete.
Self-organization principles offer a more comprehensive framework for understanding naevoid pattern formation.

Purpose of the Study:

To explore the role of self-organization in the pattern formation of naevoid skin diseases.
To define and differentiate between anatomical and functional patterning in naevi.
To investigate theoretical models of self-organized naevoid patterns.

Main Methods:

Theoretical modeling of pattern formation.
Definition of anatomical and functional patterning types.
Analysis of genotype interactions and embryonic patterning cues.

Main Results:

Two types of patterning identified: anatomical (abnormal clone within pathologic skin) and functional (spatially uncorrelated clone and pathologic skin).
Theoretical models suggest self-organized patterns arise from local genotype interactions or interactions with embryonic cues.
The interaction with embryonic patterning cues presents a novel theoretical avenue.

Conclusions:

Self-organization is a key principle in understanding naevoid skin disease pattern formation.
Naevoid pattern analysis may provide unique insights into early human embryogenesis.
Further research into genotype-embryonic cue interactions is warranted.