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Updated: Jun 14, 2026
Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
Published on: March 5, 2022
Endothelial function in patients with polycystic ovary syndrome: a long-term follow-up study
Miriam Hudecova1, Jan Holte, Matts Olovsson
1Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. miriam.hudecova@kbh.uu.se
Objective:
To investigate pulse wave reflection and endothelial-dependent vasodilation in patients with polycystic ovary syndrome (PCOS) and age-matched healthy controls.
Design:
Long-term follow-up study.
Setting:
Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Patient(S):
Sixty-seven patients with PCOS and with a mean age of 43.3 years at the follow-up investigation and 66 age-matched controls.
Intervention(S):
Aplanation tonometry before and after β-2 receptor agonist (terbutaline) challenge.
Main Outcome Measure(S):
Baseline augmentation index (AI) aorta, baseline AI-radial, and change in AI-radial after terbutaline administration as a measure of endothelial-dependent vasodilation.
Result(S):
There was no difference in baseline AI-aorta between patients with PCOS and control subjects. Change in AI-radial after terbutaline administration was less pronounced in patients with PCOS compared with control subjects. This difference remained when adjusted for use of combined oral contraceptives (OC)/hormone replacement therapy (HT) and postmenopausal status but not after adjustment for body mass index (BMI).
Conclusion(S):
Middle-aged patients with PCOS display signs of endothelial dysfunction in comparison to age-matched controls, but this is largely due to the increased prevalence of independent risk factors for cardiovascular disease found in this group.
