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Updated: Jun 14, 2026

Synthesis and Evaluation of a Ruthenium-based Mitochondrial Calcium Uptake Inhibitor
Published on: October 26, 2017
Highly selective acetate optical sensing of a ruthenium(II) complex carrying imidazole and indole groups
Huai-Xia Yang1, Yan-Ju Liu, Lin Zhao
1Pharmacy College, Henan University of Traditional Chinese Medicine, Zhengzhou 450008, China.
Abstract:
The effects of addition of F(-), Cl(-), Br(-), I(-), NO(3)(-), H(2)PO(4)(-), and OAc(-) on the UV-vis and emission spectra of Ru(II) complex [Ru(bpy)(2)(H(2)iip)](ClO(4))(2) {bpy=2,2'-bipyridyl, H(2)iip=2-indole-3-yl-imidazole[4,5-f][1,10]-phenanthroline} in dimethyl sulfone were studied. The Ru(II) complex was evidenced to be a highly selective optical sensor for OAc(-). Addition of OAc(-) elicited a distinct change in color from yellow to light orange which can be detected by naked-eye, and an almost vanished emission of the Ru(II) complex at a much lower concentration of OAc(-) than those of the other anions.
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