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Related Concept Videos

Toxic Reactions: Overview01:26

Toxic Reactions: Overview

When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...

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Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India
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Case study on industrial hazmat response teams.

Shelly J Stephens1

  • 1Amway, Ada, MI 49331, USA. shelly.stephens@amway.com

Journal of Business Continuity & Emergency Planning
|April 10, 2010
PubMed
Summary

Amway

Area of Science:

  • Industrial Safety
  • Environmental Management
  • Corporate Emergency Response

Background:

  • Amway established an industrial hazardous materials (hazmat) team in 1991 to manage chemical spills.
  • The initial team was well-funded, comprising a dedicated department with management and nearly 100 volunteers.
  • Goals included protecting employees, the community, and the environment, while minimizing operational downtime.

Purpose of the Study:

  • To document the evolution and reorganisation of Amway's hazmat team.
  • To analyze the process of re-evaluating and restructuring the response function.
  • To highlight the adaptation of the hazmat team to changing business conditions.

Main Methods:

  • Case study analysis of Amway's hazmat team.

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  • Review of the team's structure and function before and after reorganisation.
  • Evaluation of the process of systematic reinvention for lean operations.
  • Main Results:

    • The hazmat team's response function was maintained post-reorganisation.
    • The team was restructured and reinvented to operate in a lean manner.
    • Corporate goals for safety and environmental protection were consistently met.

    Conclusions:

    • Amway successfully adapted its hazmat team to a new business structure.
    • Lean principles were applied to maintain response effectiveness while integrating contract work.
    • The case demonstrates successful reorganisation of an industrial emergency response team.