Risk of low birth weight and stillbirth associated with indoor air pollution from solid fuel use in developing
Daniel P Pope1, Vinod Mishra, Lisa Thompson
1Division of Public Health, School of Population, Community and Behavioural Sciences, University of Liverpool, Whelan Building, Quadrangle, Liverpool L69 3GB, United Kingdom. danpope@liverpool.ac.uk
Insights
Indoor air pollution from solid fuel use significantly increases the risk of low birth weight and stillbirth. This exposure affects millions of pregnant women globally, contributing to substantial population health risks.
Area of Science:
- Environmental Health
- Reproductive Health
- Public Health
Background:
- Indoor air pollution from solid fuel use (IAP) is a major global health concern, linked to millions of deaths annually.
- Emerging evidence suggests IAP may negatively impact pregnancy outcomes, including birth weight and stillbirth rates.
Purpose of the Study:
- To systematically review and meta-analyze the association between IAP exposure and adverse pregnancy outcomes.
- To quantify the relationship between IAP and low birth weight (LBW) and stillbirth.
Main Methods:
- Systematic reviews and fixed-effect meta-analyses were conducted.
- Studies reporting mean birth weight, percentage of low birth weight (<2,500 g), and/or stillbirth in relation to IAP were identified and analyzed.
- Data from five LBW studies and three stillbirth studies were included.
Main Results:
- IAP exposure was significantly associated with an increased risk of low birth weight (OR=1.38) and stillbirth (OR=1.51).
- Mean birth weight was reduced by 95.6 g in infants exposed to IAP.
- Population attributable risks for LBW and stillbirth due to IAP were estimated at 21% and 26%, respectively.
Conclusions:
- IAP is a significant risk factor for low birth weight and stillbirth globally.
- Given high exposure rates in developing countries, IAP contributes substantially to adverse birth outcomes.
- Interventions to reduce IAP exposure are crucial for improving maternal and child health.
Abstract:
Exposure to indoor air pollution from solid fuel use (IAP) has been linked to approximately 1.5 million annual deaths (World Health Organization (http://www.who.int/indoorair/publications/fuelforlife/en/index.html)) due to acute lower respiratory infections in children <5 years of age and chronic obstructive lung disease and lung cancer in adults. Emerging evidence suggests that IAP increases the risk of other conditions, including adverse pregnancy outcomes. To establish the relation of IAP with birth weight and stillbirth, systematic reviews with meta-analyses were conducted. Studies reporting outcomes of mean birth weight, percentage of low birth weight (LBW; <2,500 g), and/or stillbirth and assessing IAP were identified. Five LBW studies (of 982) and 3 stillbirth studies (of 171) met inclusion criteria for the reviews. Fixed-effect meta-analyses (I(2) = 0%) found that IAP was associated with increased risk of percentage LBW (odds ratio = 1.38, 95% confidence interval: 1.25, 1.52) and stillbirth (odds ratio = 1.51, 95% confidence interval: 1.23, 1.85) and reduced mean birth weight (-95.6 g, 95% confidence interval: -68.5, -124.7). Evidence from secondhand smoke, ambient air pollution, and animal studies--and suggested plausible mechanisms--substantiate these associations. Because a majority of pregnant women in developing countries, where rates of LBW and stillbirth are high, are heavily exposed to IAP, increased relative risk translates into substantial population attributable risks of 21% (LBW) and 26% (stillbirth).
Related Concept Videos
Chronic Obstructive Pulmonary Disease I: Introduction
Breathing
Asthma-I: Introduction
Other Pulmonary Disorders
Types of Toxins
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Pulmonary Cycle: Exhalation

