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Updated: Jun 14, 2026
Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
Effects of alpha-DT cement with hydroxypropyl cellulose on bone augmentation within a titanium cap in the rabbit
Tomihisa Fukuyama1, Shuichi Sato, Yasumasa Fukase
1Division of Applied Oral Sciences, Nihon University Graduate School of Dentistry, Chiyoda-ku, Tokyo, Japan.
Abstract:
The present study was performed to evaluate the effects of calcium phosphate cement (alpha-DT cement) containing alpha-TCP, dicalcium phosphate anhydrous, and tetracalcium phosphate mixed with hydroxypropyl cellulose (HPC) for bone augmentation within a titanium cap in the rabbit calvarium. A total of 24 male adult Japanese white rabbits were used in this study. In each rabbit, one side of the cap was filled with alpha-DT cement (alpha-DT) or alpha-DT cement mixed with HPC (alpha-DTH), and the other side of the cap was left empty (control). After 1 and 3 months, newly generated tissue and mineralized bone areas were measured histomorphometrically. Significant differences in newly generated tissue and mineralized tissue were observed between the alpha-DT or alpha-DTH group and the control at 3 months. Furthermore, alpha-DTH showed significantly more mineralized tissue than alpha-DT group. Our findings indicated that although alpha-DT cement was effective for bone augmentation, alpha-DTH was more useful than alpha-DT for bone maturation.
