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Published on: September 26, 2018
Cardiovascular risk stratification in unselected primary care patients with newly detected arterial hypertension
Thomas Dieterle1, Joerg-Peter Sigle, Gunar Bengel
1Medical Outpatient Department, University Hospital Basel, Basel, Switzerland. dieterlet@uhbs.ch
Insights
Newly detected arterial hypertension patients often have high cardiovascular risk. Many exhibit multiple risk factors and target organ damage, necessitating early intervention for better outcomes.
Area of Science:
- Cardiology
- Hypertension Research
- Preventive Medicine
Background:
- Cardiovascular risk (CVR) stratification is crucial for managing arterial hypertension.
- Limited data exist on CVR factors (CVRFs), target organ damage (TOD), and overall CVR in newly diagnosed hypertensive outpatients.
Purpose of the Study:
- To assess CVRFs, TOD, and overall CVR in general medical outpatients with newly detected arterial hypertension.
- To analyze the prevalence of these factors using comprehensive diagnostic methods.
Main Methods:
- Screened 2615 outpatients for elevated office blood pressure (OBP).
- Analyzed data from 212 patients with newly detected hypertension, including OBP, ambulatory blood pressure (ABP) monitoring, fundoscopy, urinalysis, ECG, and echocardiography.
- Calculated CVR using WHO/ISH guidelines.
Main Results:
- 76.9% of patients had sustained hypertension based on ABP monitoring.
- 61.3% had 1-2 CVRFs, and 33.0% had ≥3 CVRFs.
- 26.4% showed TOD, 5.6% had diabetes, and 7.1% had associated clinical conditions (ACCs).
- 71.7% of patients were classified as high CVR risk.
Conclusions:
- Newly detected arterial hypertension in general medical outpatients is frequently associated with multiple CVRFs, TOD, and ACCs.
- The majority of these patients present with high overall cardiovascular risk, underscoring the need for early and comprehensive management.
- No significant differences in CVRFs, TOD, or ACCs were observed between white coat and sustained hypertensives.
Abstract:
Cardiovascular risk (CVR) stratification in patients with arterial hypertension is essential. Few data are available on CVR factors (CVRFs), hypertensive target organ damage (TOD) and overall CVR in medical outpatients with newly detected arterial hypertension. General medical patients entering the Medical Outpatient Department of the University Hospital Basel, Switzerland, were screened for elevated office blood pressure (OBP of >140/90 mm Hg). Patients with newly detected arterial hypertension (elevated OBP at two consultations) underwent a work-up that included fundoscopy, urinalysis, ambulatory blood pressure (ABP) monitoring, ECG and echocardiography. CVR was calculated according to the 1999/2003 World Health Organization/International Society of Hypertension (WHO/ISH) guidelines. A total of 2615 outpatients were screened. Of 580 patients with elevated first OPB, 207 were treated for hypertension, 98 refused to participate, 8 were early dropouts and 36 had a normal second OBP. Data from 212 patients were analyzed (mean age 53+/-14 years). The first and second OBP readings were 162+/-6/100+/-6 and 153+/-14/96+/-9 mm Hg, respectively. Mean ABP was 134+/-12/83+/-9 mm Hg, and sustained hypertension was found in 76.9% of patients. Among patients with hypertension according to OPB monitoring, 61.3% had 1 or 2 CVRFs, and 33.0% had >or=3 CVRFs. Evidence of TOD, diabetes or associated clinical conditions (ACCs), such as renal or cardiovascular disease, was found in 26.4, 5.6 and 7.1% of patients, respectively. In terms of CVR, 2.4% of patients were at low risk, 25.9% at medium risk and 71.7% at high risk. No differences existed between white coat and sustained hypertensives regarding CVRFs, TOD or ACCs. Comprehensive analysis in patients with newly detected arterial hypertension revealed a surprisingly high prevalence of CVRFs, TOD and ACCs, indicating high CVR in the majority of these patients.
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