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Updated: Jun 14, 2026

Laser-free Hydroxyl Radical Protein Footprinting to Perform Higher Order Structural Analysis of Proteins
Published on: June 4, 2021
Sensitive and selective time-gated luminescence detection of hydroxyl radical in water
Sarah E Page1, Kyle T Wilke, Valérie C Pierre
1Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, MN 55455, USA.
Abstract:
A terbium probe for the selective time-gated detection of hydroxyl radical is presented. This probe demonstrates high sensitivity with an 11.0-fold increase in time-gated luminescence intensity for an hour-long exposure to hydroxyl radical concentration in the femtomolar range, and high selectivity for HO* over other reactive oxygen species.
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