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A rapid field-use assay for mismatch number and location of hybridized DNAs

I-Fang Cheng1, Satyajyoti Senapati, Xinguang Cheng

  • 1Institute of Nanotechnology and Microsystems Engineering, Institute of Biomedical Engineering, Center for Micro/Nano Science and Technology, National Cheng Kung University, Tainan, Taiwan, ROC.

Lab on a Chip
|April 10, 2010
PubMed

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Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...