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[Glomerular filtration and associated factors in hypertensive individuals treated at primary care level]

Ana Karina Teixeira da Cunha França1, Alcione Miranda dos Santos, Isabela Leal Calado

  • 1Universidade Federal do Maranhão, São Luís, MA, Brasil. karinafranca2@yahoo.com.br

Arquivos Brasileiros De Cardiologia
|April 10, 2010
PubMed

Insights

High rates of reduced glomerular filtration (GF) were observed in hypertensive individuals in Brazil. Age over 65 and smoking were key factors associated with decreased kidney function, highlighting the need for proactive monitoring.

Area of Science:

  • Nephrology
  • Cardiology
  • Public Health

Background:

  • Arterial hypertension (AH) is a major risk factor for chronic kidney disease (CKD) in Brazil.
  • Monitoring glomerular filtration (GF) is crucial for assessing kidney function in hypertensive patients, as decreased GF precedes symptom onset.

Purpose of the Study:

  • To assess glomerular filtration (GF) and identify associated factors in individuals with arterial hypertension (AH).

Main Methods:

  • A cross-sectional study involving 297 hypertensive patients (with or without diabetes mellitus) in São Luís, Maranhão.
  • Data collected included sociodemographic, nutritional status, 24-hour urine GF and microalbuminuria, blood pressure, glucose, creatinine, and lipidogram.

Main Results:

  • A high prevalence of GF < 60 ml/min was found (24.6% in AH without DM, 18.3% in AH with DM).
  • In hypertensive individuals without diabetes, reduced GF was associated with age > 65 years.
  • In hypertensive individuals with diabetes, reduced GF was associated with age > 65 years, smoking, and obesity; however, only age and smoking remained significant after adjustment.

Conclusions:

  • The prevalence of reduced GF (< 60 ml/min) is high among hypertensive patients.
  • Age over 65 and smoking habit are independently associated with reduced GF in this population.
  • Systematic GF evaluation in hypertensive individuals is essential for the secondary prevention of chronic kidney disease (CKD).
Abstract

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