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09:06
Evaluation of the Curing of Adhesive Systems by Rheological and Thermal Testing
Published on: July 3, 2020
Novel mucoadhesive system based on sulfhydryl-acrylate interactions
Maya Davidovich-Pinhas1, Havazelet Bianco-Peled
1Department of Chemical Engineering, Technion, 32000 Haifa, Israel.
Journal of Materials Science. Materials in Medicine
|April 10, 2010
Summary
This study introduces a new mucoadhesive system that covalently bonds to mucus, offering strong adhesion and sustained drug release. This novel polymer hydrogel demonstrates potential for advanced drug delivery applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Drug Delivery Systems
Background:
- Mucoadhesion is crucial for effective drug delivery, requiring strong and stable bonding to mucosal surfaces.
- Existing mucoadhesive systems often lack covalent interaction, limiting their adhesion strength and duration.
- Mucin glycoproteins present in mucus are key targets for developing advanced mucoadhesive materials.
Purpose of the Study:
- To develop a novel cross-linked mucoadhesive system capable of covalent interaction with mucin.
- To demonstrate the system's potential as a sustained release matrix for hydrophilic drugs.
- To validate the covalent bonding mechanism and mucoadhesive properties of the developed system.
Main Methods:
- Synthesis of polyethylene glycol di-acrylate (PEG-DA) macromers for in situ hydrogel formation.
- Verification of mucin-polymer interactions using Nuclear Magnetic Resonance (NMR) spectroscopy.
- Rheological measurements to assess viscosity changes indicative of bonding.
- Tensile measurements to evaluate mucoadhesion strength.
Main Results:
- NMR studies confirmed covalent bond formation via the disappearance of PEG-DA vinyl protons upon mucin addition.
- Rheology experiments showed a significant viscosity increase, supporting the formation of a mucin-polymer network.
- Tensile measurements indicated PEG-DA exhibits mucoadhesion strength comparable to existing covalently interacting polymers.
- PEG-DA hydrogels demonstrated suitability for the sustained release of Ibuprofen.
Conclusions:
- A novel cross-linked mucoadhesive system based on PEG-DA has been successfully developed.
- The system forms covalent bonds with mucin glycoproteins through a Michael-type addition reaction.
- PEG-DA exhibits robust mucoadhesion and serves as an effective matrix for sustained drug release.
- This technology holds promise for enhanced topical and localized drug delivery applications.
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