Iridoid glycosides from Saprosma ternatum

Area of Science:

• Phytochemistry
• Natural Products Chemistry
• Pharmacognosy

Background:

• Saprosma ternata Hook. f. is a plant species with potential medicinal properties.
• Iridoid glycosides are a class of natural compounds known for diverse biological activities.
• Previous phytochemical investigations of Saprosma species have identified various bioactive compounds.

Purpose of the Study:

• To isolate and characterize new iridoid glycosides from Saprosma ternata leaves.
• To evaluate the antioxidant potential of the isolated compounds using established bioassays.
• To contribute to the understanding of the chemical constituents and bioactivity of Saprosma ternata.

Main Methods:

• Phytochemical analysis involving 85% ethanol extraction of Saprosma ternata leaves.
• Structure elucidation of isolated compounds using spectroscopic techniques (NMR, MS) and chemical methods.
• In vitro antioxidant activity assessment using DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) assays.

Main Results:

• Isolation of three novel iridoid glycosides: epiasperuloside (1), epipaederosidic acid (2), and epipaederoside (3).
• Identification of seven known compounds from the same plant extract.
• Epiasperuloside (1) exhibited significant antioxidant activity in both DPPH and ABTS assays.
• Other isolated compounds were also evaluated for their antioxidant capacity.

Conclusions:

• The phytochemical investigation of Saprosma ternata led to the discovery of new iridoid glycosides.
• Epiasperuloside (1) possesses notable antioxidant properties, warranting further investigation for its therapeutic potential.
• The study expands the knowledge of iridoid glycosides and their biological activities from the Saprosma genus.