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Antimicrobial activity of glucoprotamin-containing disinfectants

Stefan Tyski1, Wanda Grzybowska, Sabina Grzeszczuk

  • 1Department of Antibiotics and Microbiology, National Medicines Institute, Warsaw, Poland. tyski@il.waw.pl

Polish Journal of Microbiology
|April 13, 2010
PubMed

Insights

Glucoprotamin, the active ingredient in Incidin Plus and Sekusept Plus, demonstrates potent antimicrobial activity. This disinfectant is highly effective against both standard and resistant bacterial and fungal strains, showcasing rapid bactericidal and fungicidal properties.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Antimicrobial resistance is a growing concern with the introduction of new antimicrobial agents.
  • Disinfectants play a crucial role in preventing infections in healthcare settings.
  • Understanding the efficacy of disinfectants against diverse microbial strains is essential.

Purpose of the Study:

  • To evaluate the antimicrobial activity of glucoprotamin-based disinfectants (Incidin Plus and Sekusept Plus).
  • To assess the efficacy of these disinfectants against standard and clinical bacterial and fungal strains.
  • To determine the effectiveness of glucoprotamin against antibiotic-resistant microorganisms.

Main Methods:

  • Utilized standard bacterial and fungal strains recommended by European Standards (EN 1040:2005 and EN 1275:2005).
  • Tested 60 clinical bacterial isolates, including multiresistant strains.
  • Included 184 clinical fungal isolates from hospitalized and outpatient settings.

Main Results:

  • Glucoprotamin exhibited rapid and effective bactericidal and fungicidal activity.
  • A low concentration of glucoprotamin (0.5%) was highly effective (1 minute) against clinical bacterial isolates.
  • Incidin Plus demonstrated significant efficacy (5 minutes) against clinical fungal isolates.

Conclusions:

  • Glucoprotamin is a potent antimicrobial agent effective against a broad spectrum of microorganisms.
  • The disinfectants containing glucoprotamin are valuable tools for infection control, particularly against resistant strains.
  • Rapid action and effectiveness at low concentrations highlight the clinical utility of glucoprotamin-based disinfectants.

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