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Updated: Jun 14, 2026

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice

Published on: April 7, 2014

Perimenopausal obesity.

Colleen Keller¹, Linda Larkey, Johanna K Distefano

¹College of Nursing and Healthcare Innovation, Arizona State University, Phoenix, Arizona 85004, USA. colleen.keller@asu.edu

Journal of Women'S Health (2002)

|April 13, 2010

Summary

This summary is machine-generated.

Obesity is a major risk factor for diseases like heart disease and diabetes. This review explores how menopause and other factors contribute to weight gain in aging women, suggesting an ecological approach for management.

Related Experiment Videos

Last Updated: Jun 14, 2026

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice

Published on: April 7, 2014

Area of Science:

Reproductive Endocrinology
Obesity Research
Public Health

Background:

Obesity is a significant risk factor for chronic diseases such as heart disease and diabetes.
Women, particularly during life transitions like menopause, are prone to weight gain.
Multiple interacting factors contribute to obesity, including energy intake, physical activity, and fat distribution.

Purpose of the Study:

To review the literature on weight change during perimenopause.
To examine contributing factors from an ecological perspective.
To recommend future research directions for weight management in women.

Main Methods:

Literature review using a multilevel perspective.
Analysis of factors across community, family, and individual levels.
Integration of biological, genetic, and behavioral predispositions.

Main Results:

Menopause triggers changes that can lead to weight gain in aging women.
The interaction of multiple factors determines an individual's risk for obesity.
An ecological framework is essential for understanding weight change in perimenopausal women.

Conclusions:

Weight management in perimenopausal women requires an integrated, multilevel approach.
Future research should focus on translational strategies tailored to women's unique needs.
Addressing obesity during perimenopause is crucial for long-term health outcomes.