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Updated: Jun 14, 2026

ODELAY: A Large-scale Method for Multi-parameter Quantification of Yeast Growth
11:19

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Published on: July 3, 2017

Bayesian multi-QTL mapping for growth curve parameters.

Henri C M Heuven1, Luc L G Janss

  • 1Clinical Sciences of Companion Animals Faculty of Veterinary Medicine, Utrecht University P,O, box 80163, 3508 TD Utrecht, The Netherlands . h.c.m.heuven@uu.nl.

BMC Proceedings
|April 13, 2010
PubMed
Summary

This study identified nine quantitative trait loci (QTLs) influencing repeated growth measurements in simulated data. Most QTLs were precisely located, aiding in understanding genetic correlations for growth parameters.

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Area of Science:

  • Genetics
  • Quantitative Genetics
  • Bioinformatics

Background:

  • Analyzing repeated measures in experimental units presents challenges due to non-independence and temporal trends.
  • Non-linear increases in mean and variance over time complicate the identification of quantitative trait loci (QTLs).

Purpose of the Study:

  • To develop and apply a two-step approach for identifying QTLs in simulated data with repeated, non-linear measurements.
  • To analyze latent variables summarizing growth curves and perform genome-wide association studies.

Main Methods:

  • A two-step approach was employed, summarizing repeated measurements into latent variables using logistic growth curves.
  • Genome-wide analysis of these latent variables was conducted using a Bayesian algorithm and an 'animal' model.

Main Results:

  • Heritabilities were estimated at ~48% for asymptote (ASYM) and scaling factor (SCAL), and ~24% for inflection point (XMID).
  • Genome-wide scans identified four QTLs for ASYM, one for XMID, and four for SCAL, with varying effect sizes and localizations.
  • Close QTL locations suggested genetic correlations between ASYM, XMID, and SCAL.

Conclusions:

  • At least nine QTLs were found to affect repeated observations across different growth parameters.
  • Precise localization was achieved for most QTLs, though the XMID QTL may involve two linked QTLs on chromosome one.