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[Protective effect of recombinant HMGB1 A box protein in mouse with acute hepatic failure]
1Department of Infectious Disease, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Objective:
To evaluate the effect of recombinant HMGB1 A box protein in mouse with acute hepatic failure.
Method:
Acute hepatic failure was induced by D-galactosamine and lipopolysaccharide in mice. After injection with saline (control) or recombinant HMGB1 A box proteins, the expression of HMGB1 in liver tissues was detected by immunohistochemistry and RT-PCR, and the serum TNFalpha and IL-1beta were quantified.
Results:
rHMGB1-Abox protein alleviated the acute liver damage. rHMGB1-Abox protein treatment decreased the expression of HMGB1 in liver tissues and reduced the serum levels of TNFalpha and IL-1beta.
Conclusion:
rHMGB1-Abox protein can alleviate the acute liver damage and inhibit the expression of HMGB1.
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