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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...

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Related Experiment Video

Updated: Jun 14, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Long non-coding RNAs in nervous system function and disease.

Irfan A Qureshi1, John S Mattick, Mark F Mehler

  • 1Rosyln and Leslie Goldstein Laboratory for Stem Cell Biology and Regenerative Medicine, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA.

Brain Research
|April 13, 2010
PubMed
Summary
This summary is machine-generated.

Long non-protein-coding RNAs (lncRNAs) are crucial epigenetic regulators in the central nervous system (CNS). Their dysregulation is linked to various CNS disorders, highlighting their role in neurological and psychiatric diseases.

Related Experiment Videos

Last Updated: Jun 14, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Area of Science:

  • Neuroscience
  • Epigenetics
  • Molecular Biology

Background:

  • Epigenetic mechanisms control gene expression in the central nervous system (CNS), influencing development, homeostasis, and stress responses.
  • Disruptions in epigenetic processes are linked to neurological and psychiatric diseases.
  • Long non-protein-coding RNAs (lncRNAs) are increasingly recognized as key players directing epigenetic machinery.

Purpose of the Study:

  • To review the expression and function of lncRNAs in the CNS.
  • To highlight the role of lncRNAs in CNS development, homeostasis, stress responses, and plasticity.
  • To discuss the implication of lncRNA deregulation in CNS pathologies.

Main Methods:

  • Literature review of recent studies on lncRNA expression and function in the CNS.
  • Analysis of evidence linking lncRNAs to epigenetic mechanisms like chromatin remodeling.
  • Examination of lncRNA involvement in cell identity and CNS processes.

Main Results:

  • LncRNAs are extensively expressed in the CNS in a cell type-specific manner.
  • LncRNAs direct chromatin remodeling complexes to specific genomic sites.
  • LncRNAs are critical for neuronal and glial cell subtype generation and CNS functions.

Conclusions:

  • LncRNA deregulation is implicated in the pathogenesis of diverse CNS disorders.
  • LncRNAs are essential for maintaining CNS identity and function.
  • Further research into lncRNAs offers potential therapeutic avenues for CNS diseases.