Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clodronate exerts an anabolic effect on articular chondrocytes mediated through the purinergic receptor pathway.

Osteoarthritis and cartilage·2014
Same author

The effect of moving point of contact stimulation on chondrocyte gene expression and localization in tissue engineered constructs.

Annals of biomedical engineering·2013
Same author

Patient-specific modelling of the foot: automated hexahedral meshing of the bones.

Computer methods in biomechanics and biomedical engineering·2012
Same author

Chondrocyte repopulation of the zone of death induced by osteochondral harvest.

Osteoarthritis and cartilage·2010
Same author

Effects of dehydration-induced structural and material changes on the apparent modulus of cancellous bone.

Medical engineering & physics·2010
Same author

Harnessing the purinergic receptor pathway to develop functional engineered cartilage constructs.

Osteoarthritis and cartilage·2010

Related Experiment Video

Updated: Jun 14, 2026

Practical Considerations for the Design, Execution, and Interpretation of Studies Involving Whole-Bone Bending Tests of Rodent Bones
04:20

Practical Considerations for the Design, Execution, and Interpretation of Studies Involving Whole-Bone Bending Tests of Rodent Bones

Published on: September 1, 2023

Specimen diameter and "side artifacts" in cancellous bone evaluated using end-constrained elastic tension.

W B Lievers1, A C Petryshyn, A S Poljsak

  • 1Department of Mechanical and Materials Engineering, Queen's University, Kingston, Ontario, Canada K7L 3N6.

Bone
|April 13, 2010
PubMed
Summary
This summary is machine-generated.

Increasing cancellous bone specimen diameter minimizes artifacts. Larger diameters, specifically 8.3 mm and above, yield accurate mechanical properties, essential for comparing bone architectures.

More Related Videos

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance
06:54

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Published on: February 13, 2026

Assessment of Bone Fracture Healing Using Micro-Computed Tomography
12:04

Assessment of Bone Fracture Healing Using Micro-Computed Tomography

Published on: December 9, 2022

Related Experiment Videos

Last Updated: Jun 14, 2026

Practical Considerations for the Design, Execution, and Interpretation of Studies Involving Whole-Bone Bending Tests of Rodent Bones
04:20

Practical Considerations for the Design, Execution, and Interpretation of Studies Involving Whole-Bone Bending Tests of Rodent Bones

Published on: September 1, 2023

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance
06:54

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Published on: February 13, 2026

Assessment of Bone Fracture Healing Using Micro-Computed Tomography
12:04

Assessment of Bone Fracture Healing Using Micro-Computed Tomography

Published on: December 9, 2022

Area of Science:

  • Biomaterials Science
  • Orthopedic Biomechanics
  • Materials Science

Background:

  • Cancellous bone mechanical properties are crucial for understanding bone health and disease.
  • Specimen preparation can introduce artifacts, underestimating in situ mechanical properties.
  • Existing methods like finite element method (FEM) models offer correction factors for these artifacts.

Purpose of the Study:

  • To investigate the effect of specimen diameter on cancellous bone mechanical properties.
  • To determine the minimum specimen diameter required to avoid side artifacts.
  • To validate experimental findings with numerical simulations.

Main Methods:

  • Mechanical testing of six different diameter specimens (3.1-10.6 mm) in elastic tension.
  • Utilized an epoxy endcap protocol to eliminate end artifacts.
  • Created FEM models from micro-CT images of cancellous bone.

Main Results:

  • Elastic modulus was significantly affected by specimen diameter in both bovine femoral condyle and lumbar vertebrae.
  • Specimens with diameters of 8.3 mm and 10.6 mm showed no statistical difference, indicating artifact avoidance.
  • FEM models confirmed that modulus approaches an asymptotic value with increasing diameter.

Conclusions:

  • Increasing specimen diameter effectively minimizes side artifacts in cancellous bone testing.
  • A minimum diameter of 8.3 mm is suggested to ensure accurate measurement of mechanical properties.
  • Specimen diameter selection is critical when comparing groups with different bone architectures to avoid confounding results.