Related Experiment Video

Updated: Jun 14, 2026

Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts
11:15

Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts

Published on: September 1, 2018

GM-CSF-armed, replication-competent viruses for cancer

James M Burke1

  • 1Billings Clinic, Department of Hematology and Oncology, United States. jburke@billingsclinic.org

Cytokine & Growth Factor Reviews
|April 13, 2010
PubMed

Insights

Monoclonal antibody therapy has advanced cancer treatment. New research explores virus-based tumor vaccines, like GM-CSF armed vectors, showing promising early clinical results for cancer immunotherapy.

Area of Science:

  • Oncology
  • Immunotherapy
  • Virology

Background:

  • Monoclonal antibody therapy has revolutionized cancer treatment after initial challenges.
  • Understanding technical limitations paved the way for current successes.
  • Exploiting the immune system remains a key strategy in cancer research.

Purpose of the Study:

  • To review current research on tumor vaccine strategies.
  • To highlight the role of virus-based immune agents in cancer therapy.
  • To discuss early clinical trial results of GM-CSF armed vectors.

Main Methods:

  • Review of existing literature on virus-based immune agents.
  • Focus on herpes, adenovirus, and vaccinia vectors.
  • Analysis of early clinical trial data for GM-CSF encoding vectors.

Main Results:

  • Intriguing early clinical trial results reported for virus-based immune agents.
  • GM-CSF armed vectors show potential in cancer vaccine strategies.
  • Herpes, adenovirus, and vaccinia vectors are being investigated.

Conclusions:

  • Virus-based immune agents, including GM-CSF armed vectors, represent a promising area of cancer immunotherapy research.
  • Early clinical data suggest potential efficacy, warranting further investigation.
  • These strategies aim to further exploit the immune system for cancer treatment.

More Related Videos

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus11:28

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Published on: October 7, 2011

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...