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80 causes, predispositions, and pathways of laminitis
18621A Hunters Drive, Frederick, MD 21701, USA. horseu@earthlink.net
The Veterinary Clinics of North America. Equine Practice
|April 13, 2010
Summary
Laminitis causes were historically observational. Recent decades brought many new theories, but few are experimentally confirmed, and this article reviews them.
Area of Science:
- Equine Health
- Veterinary Science
- Animal Physiology
Background:
- Laminitis etiology has traditionally relied on observational data.
- Scientific understanding of laminitis has evolved significantly over the past three decades.
Purpose of the Study:
- To review and highlight the various theories regarding the causes of laminitis.
- To provide an overview of the experimental validation of laminitis theories.
Main Methods:
- Literature review of historical and contemporary laminitis research.
- Analysis of experimental evidence supporting different etiological theories.
Main Results:
- A substantial increase in proposed laminitis theories in recent years.
- A limited number of these theories have undergone rigorous experimental confirmation.
Conclusions:
- The understanding of laminitis causes is expanding rapidly, driven by new research.
- Further experimental validation is crucial to solidify our knowledge of laminitis pathogenesis.
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