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Related Concept Videos

American Trypanosomiasis01:22

American Trypanosomiasis

Chagas disease, or American trypanosomiasis, is a vector-borne parasitic infection caused by Trypanosoma cruzi, a flagellated protozoan (kinetoplastid) of the family Trypanosomatidae. The disease is endemic in Latin America, although cases are increasingly reported worldwide due to human migration. Transmission most commonly occurs when feces of infected triatomine bugs contaminate bite wounds or mucosal surfaces; additional routes include congenital, transfusional, transplant-related, and oral...
Diversity of Protists I01:15

Diversity of Protists I

Excavata is a diverse group of protists that includes both chemoorganotrophic and phototrophic species, with some thriving in anaerobic environments. Among the key groups within Excavata are diplomonads and parabasalids, which are flagellated protists that lack mitochondria and chloroplasts. These microorganisms typically inhabit anoxic environments, such as the intestines of animals, where they exist either symbiotically or as parasites, relying on fermentation for energy production. Some...
Diversity of Protists IV01:27

Diversity of Protists IV

Amoebozoa represent a diverse group of terrestrial and aquatic protists that utilize lobe-shaped pseudopodia for locomotion and feeding. This characteristic differentiates them from the Rhizaria, which possess threadlike pseudopodia. The primary classifications within Amoebozoa include gymnamoebas, entamoebas, and the plasmodial and cellular slime molds. Phylogenetic evidence indicates that Amoebozoa diverged from a lineage that ultimately gave rise to fungi and animals.Gymnamoebas and...
Diversity of Protists II01:27

Diversity of Protists II

Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
Diversity of Protists III01:27

Diversity of Protists III

Rhizaria are a diverse group of unicellular protists characterized by their threadlike cytoplasmic extensions known as pseudopodia. These structures aid in both locomotion and feeding, giving Rhizaria an amoeboid appearance. Their amoeboid morphology once led to taxonomic confusion, but molecular phylogenetics has clarified their evolutionary placement and emphasized their shared use of pseudopodia despite divergent lineages.This clade comprises diverse lineages such as Chlorarachniophyta,...
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Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...

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Superior Auto-Identification of Trypanosome Parasites by Using a Hybrid Deep-Learning Model
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African trypanosomes: celebrating diversity.

Emily R Adams1, Patrick B Hamilton, Wendy C Gibson

  • 1Koninklijk Instituut voor de Tropen (KIT) Biomedical Research, Amsterdam 1105 AZ, Netherlands.

Trends in Parasitology
|April 13, 2010
PubMed
Summary
This summary is machine-generated.

New tsetse-fly transmitted trypanosomes in Africa are emerging, challenging our understanding of these known pathogens. Further research is crucial to assess their impact on livestock and disease control strategies.

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High-throughput Gene Tagging in Trypanosoma brucei
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High-throughput Gene Tagging in Trypanosoma brucei

Published on: August 12, 2016

Area of Science:

  • Veterinary Parasitology
  • Molecular Phylogenetics
  • Tropical Medicine

Background:

  • Tsetse-transmitted trypanosomes are significant pathogens causing human and animal diseases.
  • Recent molecular techniques have uncovered previously unknown trypanosome diversity in Africa.
  • This genetic diversity is often overlooked despite its potential implications.

Purpose of the Study:

  • To highlight the existence of novel tsetse-transmitted trypanosomes.
  • To emphasize the need for taxonomic recognition of this increased diversity.
  • To advocate for further investigation into their biological and clinical significance.

Main Methods:

  • Advanced molecular identification techniques.
  • Phylogenetic analysis of trypanosome genetic data.
  • Comparative analysis with known trypanosome species.

Main Results:

  • Identification of multiple previously unrecognized trypanosome species.
  • Demonstration of significant genetic divergence within these novel trypanosomes.
  • Evidence of pathogenicity in some newly identified trypanosomes.

Conclusions:

  • The diversity of tsetse-transmitted trypanosomes is greater than currently recognized.
  • Novel trypanosomes warrant taxonomic classification and further study.
  • Investigating host range, pathogenicity, and treatment response is essential for effective disease management.