Predictive value of ovarian reserve markers in smoking and non-smoking women undergoing IVF

Ovarian reserve markers are now widely used in IVF centres in order to predict ovarian response and adapt ovarian stimulation protocols. In this study, the respective performance of day-3 FSH, oestradiol and anti-Müllerian hormone concentrations and antral follicle count for the prediction of poor ovarian response to ovarian stimulation and pregnancy in IVF cycles were compared in women according to their smoking status. The analysis of 384 IVF cycles showed that anti-Müllerian hormone concentration and antral follicle count were the best predictors of poor ovarian response and performed better in non-smokers than in smokers, for which no parameter could predict pregnancy.