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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

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Related Experiment Video

Updated: Jun 14, 2026

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes
10:48

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Published on: April 12, 2015

MicroRNAs in neural cell differentiation.

Pierre Lau1, Lynn D Hudson

  • 1Section of Developmental Genetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.

Brain Research
|April 13, 2010
PubMed
Summary

MicroRNAs regulate gene expression in the developing brain, creating diverse neural cells. These small RNAs are crucial for nervous system development and maintenance, ensuring robust neural networks.

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Last Updated: Jun 14, 2026

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes
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Published on: April 12, 2015

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08:37

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MicroRNA Expression Profiles of Human iPS Cells, Retinal Pigment Epithelium Derived From iPS, and Fetal Retinal Pigment Epithelium
10:19

MicroRNA Expression Profiles of Human iPS Cells, Retinal Pigment Epithelium Derived From iPS, and Fetal Retinal Pigment Epithelium

Published on: June 24, 2014

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • The mammalian nervous system's complexity arises from intricate gene expression patterns during development, leading to a vast array of neural cell types.
  • MicroRNAs (miRNAs), small non-coding RNAs abundant in the brain, are increasingly recognized for their regulatory roles in neural gene expression.

Purpose of the Study:

  • To review the recently discovered functions of microRNAs in the development and maintenance of the mammalian nervous system.
  • To highlight the significance of microRNAs in establishing neural cell diversity and network robustness.

Main Methods:

  • This review synthesizes findings from recent studies on microRNA function in neurodevelopment.
  • Analysis of temporal and spatial expression patterns of microRNAs during neural differentiation.
  • Examination of microRNA involvement in molecular feedback loops within neural networks.

Main Results:

  • MicroRNAs are temporally expressed during key stages of neural differentiation.
  • MicroRNA expression is spatially regulated within the developing brain.
  • MicroRNAs are integrated into molecular feedback loops that enhance the stability of neural networks.

Conclusions:

  • MicroRNAs play a critical role in the development and ongoing maintenance of the nervous system.
  • The precise regulation of microRNAs contributes to the generation of neural cell diversity.
  • MicroRNAs are essential components for ensuring the robustness and proper functioning of neural networks.