Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A protein interactome for the last eukaryotic common ancestor illuminates the biochemical basis of modern genetic diseases.

Cell genomics·2026
Same author

How variant discovery redefines genetic prevalence: the case of cystine stone disease.

European journal of human genetics : EJHG·2026
Same author

<i>NPHS2</i> Revisited Through 208 Cases and Podocin Complex Modeling.

Kidney international reports·2026
Same author

Precision Diagnosis in APOL1 Kidney Disease With the p.N264K M1 Protective Variant.

JAMA network open·2026
Same author

N<sup>6</sup>-adenosine methylation enhances nuclear mRNA export through METTL3 and NUP93.

Nature cell biology·2026
Same author

Identification of monogenic variants in steroid-resistant and steroid-sensitive nephrotic syndrome.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

Convergence of metabolic risk in obesity and normal BMI: does risk disappear?

Lancet (London, England)·2026
Same journal

Metabolic traits in obesity and normal BMI in industrialised countries: a multi-country analysis of national population-based studies.

Lancet (London, England)·2026
Same journal

Safety and efficacy of mRNA vaccines: a mechanistic and public health perspective.

Lancet (London, England)·2026
Same journal

The US Ebola response and the future of global health leadership.

Lancet (London, England)·2026
Same journal

Daniel Mason: a tale of change.

Lancet (London, England)·2026
Same journal

The 2026 Wakley-Wu Lien Teh Prize Essay: why medicine, and why stay?

Lancet (London, England)·2026
See all related articles

Related Experiment Video

Updated: Jun 14, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
07:35

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Published on: June 23, 2015

Genetic kidney diseases.

Friedhelm Hildebrandt1

  • 1Howard Hughes Medical Institute and Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA. fhilde@umich.edu

Lancet (London, England)
|April 13, 2010
PubMed
Summary
This summary is machine-generated.

Understanding single-gene defects and polygenic risk alleles is crucial for kidney disease. Genetic insights enable personalized medicine, improving diagnosis, prognosis, and targeted treatments for renal disorders.

More Related Videos

Evaluation of Zebrafish Kidney Function Using a Fluorescent Clearance Assay
08:13

Evaluation of Zebrafish Kidney Function Using a Fluorescent Clearance Assay

Published on: February 20, 2015

Related Experiment Videos

Last Updated: Jun 14, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
07:35

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Published on: June 23, 2015

Evaluation of Zebrafish Kidney Function Using a Fluorescent Clearance Assay
08:13

Evaluation of Zebrafish Kidney Function Using a Fluorescent Clearance Assay

Published on: February 20, 2015

Area of Science:

  • Nephrology
  • Genetics
  • Molecular Biology

Background:

  • Identifying primary disease causes is vital for understanding mechanisms, classification, prognosis, and treatment.
  • Single-gene defects are increasingly recognized as causes of kidney diseases, such as steroid-resistant nephrotic syndrome due to podocin mutations.
  • While single-gene disorders are rare, polygenic risk alleles contribute to common adult-onset diseases.

Purpose of the Study:

  • To review prominent single-gene kidney disorders and polygenic risk alleles in common kidney diseases.
  • To discuss the role of emerging sequencing techniques in molecular genetic diagnosis and treatment.
  • To highlight how genetic knowledge aids in elucidating disease mechanisms and developing targeted therapies.

Main Methods:

  • Review of current literature on single-gene kidney disorders and polygenic risk.
  • Discussion of advancements in total exome capture and large-scale sequencing technologies.
  • Analysis of the impact of genetic findings on personalized medicine and drug development.

Main Results:

  • Single-gene mutations provide a strong basis for personalized medicine, offering high predictive value for disease development.
  • Polygenic risk alleles are significant in common adult-onset kidney diseases.
  • Emerging sequencing techniques are poised to enhance molecular genetic diagnosis and prognosis.

Conclusions:

  • Knowledge of genetic causes, including single-gene defects and polygenic risk, is essential for advancing kidney disease management.
  • Personalized medicine approaches, driven by genetic insights, promise improved diagnosis, prognosis, and targeted treatments.
  • Advanced sequencing technologies will facilitate a deeper understanding of renal disease mechanisms and the development of novel therapeutic strategies.