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Published on: March 17, 2023
Alterations in circulating adiponectin levels occur rapidly after parturition
Jens Fuglsang1, Puk Sandager, Jan Frystyk
1Gynaecological/Obstetrical Research Laboratory, Gynaecological/Obstetrical Department, Clinical Institute, Aarhus University Hospital, Skejby, DK-8200 Aarhus N, Denmark. fuglsang@ki.au.dk
European Journal of Endocrinology
|April 13, 2010
Summary
Adiponectin levels significantly decrease within 24 hours after delivery, with changes in its subforms initiating the transition to non-pregnant levels. This study investigated adiponectin
Area of Science:
- Endocrinology
- Reproductive Biology
- Metabolic Health
Background:
- Adiponectin, an adipokine, plays a crucial role in metabolic regulation.
- Pregnancy is associated with altered adiponectin levels.
- Understanding post-partum changes in adiponectin is vital for metabolic health assessment.
Purpose of the Study:
- To quantify adiponectin and its subforms before and after delivery.
- To assess the impact of pregnancy cessation on circulating adiponectin.
- To elucidate the role of adiponectin subforms in the transition to the non-pregnant state.
Main Methods:
- Serum adiponectin was measured in 37 women with singleton and 6 with twin pregnancies.
- Measurements were taken before caesarean section (CS) and 24, 48 hours post-CS.
- Adiponectin subforms (high, medium, low molecular weight) were analyzed.
Main Results:
- Total serum adiponectin decreased by approximately 17-19% within 48 hours post-delivery (P<0.001).
- High-molecular weight adiponectin showed the most significant absolute decrease.
- Medium-molecular weight adiponectin decreased, while low-molecular weight adiponectin increased significantly.
Conclusions:
- Adiponectin levels rapidly decline shortly after childbirth.
- Changes in adiponectin subforms are key to the normalization of levels towards the non-pregnant state.
- These findings highlight the dynamic metabolic shifts occurring postpartum.
