Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Switchable Ultralong Chiral Signal Transmission and Gate Tunability in Organic Chiral Semiconductor.

Research (Washington, D.C.)·2026
Same author

When photocatalysts learn to store electrons.

Nature chemistry·2026
Same author

Chirality-selective optical transport of nanoparticles in the evanescent field of a nanofibre.

Nature communications·2026
Same author

Specifying the Origin of Chiral Sensitivity through Conformal Nanogap Engineering in a Single Helicoid Gold Nanoparticle.

ACS nano·2026
Same author

Influence of Charge Block Length on Conformation and Cluster Formation of Atactic Peptide Polyampholytes.

Macromolecules·2026
Same author

Low-Salt Electrochemical Synthesis of H<sub>2</sub>O<sub>2</sub> Enabled by CO<sub>2</sub>‑Mediated Radical Chemistry.

ACS omega·2026

Related Experiment Video

Updated: Jun 14, 2026

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
13:42

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Published on: November 2, 2011

Free-floating ultrathin two-dimensional crystals from sequence-specific peptoid polymers.

Ki Tae Nam1, Sarah A Shelby, Philip H Choi

  • 1Molecular Foundry; National Center for Electron Microscopy, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.

Nature Materials
|April 13, 2010
PubMed
Summary

Researchers created ultrathin, 2D crystalline sheets from protein-like peptoid polymers. This biomimetic self-assembly demonstrates precise control over polymer structure and function for advanced nanomaterials.

More Related Videos

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

Related Experiment Videos

Last Updated: Jun 14, 2026

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
13:42

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Published on: November 2, 2011

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Biomaterials

Background:

  • Designing protein-like polymers is a key challenge in materials science.
  • Understanding monomer sequence impact on polymer structure and function is crucial.
  • Peptoids offer a biomimetic route to mimic protein structure and functionality.

Purpose of the Study:

  • To investigate the aqueous self-assembly of peptoid polymers into 2D crystalline sheets.
  • To explore the role of periodic amphiphilicity, electrostatic, and aromatic interactions in directing self-assembly.
  • To demonstrate the potential of peptoid-based 2D nanostructures for specific binding applications.

Main Methods:

  • Synthesis of two oppositely charged peptoid 36mers with specific sequences.
  • Aqueous mixing of peptoid polymers in a 1:1 ratio.
  • Characterization using aberration-corrected transmission electron microscopy (TEM).
  • Demonstration of specific protein binding to functionalized sheets.

Main Results:

  • Formation of giant, free-floating 2D crystalline sheets with a thickness of 2.7 nm.
  • Direct visualization of aligned peptoid chains within the sheet structure via TEM.
  • Successful specific binding of a protein to ligand-functionalized peptoid sheets.

Conclusions:

  • Peptoid polymers can self-assemble into highly ordered, ultrathin 2D crystalline sheets in aqueous solution.
  • The self-assembly process is directed by specific molecular interactions, including amphiphilicity and electrostatics.
  • Peptoids provide a versatile platform for creating functional 2D nanostructures with potential applications in biomaterials and nanotechnology.