Comparison of optic disc topography before and after antiglaucoma treatment in juvenile glaucoma

To compare the optic disc topography parameters of cases of juvenile glaucoma before and after antiglaucoma treatment by using Heidelberg Retinal Tomograph (HRT II).

The medical records of 21 eyes of 21 consecutive patients (mean age 13+/-2 years) with juvenile glaucoma, who had been examined between 2006 and 2008, were reviewed retrospectively.The topographic optic disc parameters (cup volume, cup area, rim volume, rim area, mean cup to disc ratio and mean cup depth) and mean retinal nerve fiber layer thickness of 21 eyes of 21 children with juvenile glaucoma at baseline and at the sixth month of antiglaucoma treatment were compared with paired t test.

No statistically significant differences were found among cup volume (p=0.137), rim area (p=0.07), rim volume (p=0.102), and mean cup depth (p=0.892) before and after treatment. Mean cup area and cup to disc ratio at the sixth month of treatment were statistically significantly smaller than the values at baseline (p=0.041, p=0.002). The mean retinal nerve fiber layer at baseline was statistically significantly smaller than the value after treatment (p= 0.016).

The result suggests that glaucomatous changes of optic disc topography may be reversible after antiglaucoma treatment in juvenile glaucoma.