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Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Karyotyping01:17

Karyotyping

Describing the number and physical features of chromosomes can reveal abnormalities that underlie genetic diseases. This description is facilitated by special staining techniques that produce a particular banding pattern on each chromosome. State-of-the-art techniques make this approach even more powerful, enabling the detection of individual genes that cause disease.A Simple Chromosome Staining Technique Provides Valuable Scientific InsightSome genetic diseases can be detected by looking at...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer is an enzyme that can...

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Related Experiment Video

Updated: Jun 13, 2026

Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants
09:16

Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants

Published on: February 21, 2015

[Array CGH: why and to whom].

Alessandra Ferrarini1, Sébastien Jacquemont, Maja Beck Popovic

  • 1Service de génétique médicale et Département médico-chirurgical de pédiatrie, CHUV, 1011 Lausanne. Alessandra.Ferrarini@chuv.ch

Revue Medicale Suisse
|April 14, 2010
PubMed
Summary

Array comparative genomic hybridization (array CGH) detects tiny genetic abnormalities missed by standard methods. This advanced technique is crucial for diagnosing genetic diseases, especially in pediatrics.

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Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization
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Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization

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Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
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Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

Related Experiment Videos

Last Updated: Jun 13, 2026

Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants
09:16

Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants

Published on: February 21, 2015

Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization
16:37

Technical Demonstration of Whole Genome Array Comparative Genomic Hybridization

Published on: August 5, 2008

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
22:27

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

Area of Science:

  • Genomics
  • Human Genetics
  • Molecular Biology

Context:

  • Structural genomic abnormalities are primary causes of mental impairment, complex syndromes, and tumors.
  • Existing methodologies for detecting chromosomal abnormalities have limitations.
  • Array comparative genomic hybridization (array CGH) offers a revolutionary approach to genetic analysis.

Purpose:

  • To explain the necessity of array CGH in etiological research for genetic diseases.
  • To highlight the limitations of standard diagnostic approaches.
  • To define the application of array CGH in pediatric genetic disease diagnosis.

Summary:

  • Array CGH can characterize very small genetic abnormalities undetectable by standard methods.
  • This technique provides valuable diagnostic information even without clinical data.
  • The article discusses the application and benefits of array CGH in a pediatric setting.

Impact:

  • Enables the identification of genetic causes for previously undiagnosed disorders.
  • Improves diagnostic accuracy for complex genetic syndromes and developmental delays.
  • Facilitates earlier and more precise diagnosis in pediatric patients, guiding treatment and management.