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Published on: December 26, 2017
Patient outcomes after anti TNF-alpha drugs for Crohn's disease
Nazila Assasi1, Gord Blackhouse, Feng Xie
1Programs for Assessment of Technology in Health Research Institute, St Joseph's Healthcare, Hamilton, 25 Main Street West, Suite 2000 ON, Canada. assasin@mcmaster.ca
Abstract:
Crohn's disease (CD) is a chronic inflammatory bowel disease with a relatively high prevalence rate in North America. More than 50% of CD patients require surgery at some stage of their disease. Anti-TNF-alpha drugs are increasingly being used in patients with CD who have had an inadequate response to conventional therapy. Treatment with anti-TNF-alpha agents aims at improving symptom control and reducing the need for hospitalization and surgery. This review examines the clinical effectiveness of three anti-TNF-alpha agents (infliximab, adalimumab and etanercept) in moderate and severe CD. The review further considers the evidence for the harms and benefits associated with switching from one anti-TNF-alpha agent to another and strategies to optimize the timing of therapy.
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