Breast cancer and cerebral laterality

Area of Science:

• Neuroscience
• Oncology
• Human Genetics

Background:

• Breast cancer is a complex disease with multifactorial origins.
• Cerebral laterality, the brain's functional asymmetry, has been linked to various neurological and developmental conditions.
• Emerging research suggests potential connections between laterality, hormonal factors, and disease risk.

Purpose of the Study:

• To review and summarize institutional findings on breast cancer characteristics.
• To identify consistencies in breast cancer patients related to cerebral laterality.
• To explore the potential role of ocular pigmentation as a biomarker in breast cancer.

Main Methods:

• Retrospective review of patient data at the institution.
• Analysis of breast cancer cases for specific laterality markers.
• Correlation of laterality features with demographic and hormonal risk factors.

Main Results:

• Breast cancer cases demonstrated four distinct features of cerebral laterality.
• These features include increased left-handedness, atypical birth seasonality, advanced maternal age as a risk factor, and links to prenatal sex hormones.
• Hypopigmentation, related to cerebral laterality, suggests a potential link to breast cancer.

Conclusions:

• Breast cancer is associated with specific cerebral laterality patterns.
• Ocular pigmentation should be investigated as a potential factor in breast cancer, considering disease laterality and patient age at diagnosis.
• Further research is needed to elucidate the complex interplay between cerebral laterality, hormonal influences, and breast cancer development.