Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

mTOR Signaling and Cancer Progression

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

mTOR Signaling and Cancer Progression

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

PI3K/mTOR/AKT Signaling Pathway

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a rapamycin-insensitive companion...

Calmodulin-dependent Signaling

Calmodulin-dependent Signaling

Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...

TGF - β Signaling Pathway

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...

Cell Signaling Feedback Loops

Cell Signaling Feedback Loops

Positive and negative feedback loops are crucial for regulating biological signaling systems. These feedback loops are processes that connect output signals to their inputs.
Negative feedback loops
Most signaling systems have negative feedback loops that can perform different functions such as output limiter, and adaptation.
Output limiter
Upon receiving an input signal, the cellular response rapidly increases until a threshold is reached. Beyond this threshold, a negative feedback loop...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Quantifying the utility of type 2 diabetes polygenic risk score for predicting incident diabetes: an analysis of large US-based cohort studies.

BMC medical genomics·2026

Same author

Transcriptomic Profiling in Skeletal Muscle Identifies Associations With Knee Osteoarthritis: the Study of Muscle, Mobility and Aging (SOMMA).

medRxiv : the preprint server for health sciences·2026

Same author

Reduction of glycation stress as a geroscience intervention: protocol for a pilot RCT in postmenopausal women.

npj aging·2026

Same author

Multi ancestry genome wide association meta analysis of urinary aMT6s levels.

Scientific reports·2026

Same author

Associations of polygenic risk scores for type 2 diabetes with metabolic measures in Pacific Islanders from Guam and Saipan.

Journal of human genetics·2026

Same author

Ancestry-specific genetic effects on urinary 6-sulfatoxymelatonin: a multi-ancestry GWAS meta-analysis.

Research square·2025

Search research articles

Related Experiment Video

Updated: Jun 13, 2026

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer

Published on: April 13, 2015

TOR signaling never gets old: aging, longevity and TORC1 activity.

Daniel S Evans¹, Pankaj Kapahi, Wen-Chi Hsueh

¹Department of Medicine, University of California, San Francisco, United States.

Ageing Research Reviews

|April 14, 2010

Summary

The target of rapamycin (TOR) pathway, a conserved network regulating cell growth, influences lifespan across species. Manipulating TOR activity can extend lifespan, suggesting potential benefits for human health.

Related Experiment Videos

Last Updated: Jun 13, 2026

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer

Published on: April 13, 2015

Area of Science:

Cellular Biology
Molecular Biology
Genetics

Background:

The target of rapamycin (TOR) signaling network integrates intra- and extracellular cues to regulate cell growth.
Recent research highlights a modular organization within the TOR network, with distinct modules sensing specific signals.
TOR pathway components are highly conserved across diverse species, from yeast to mammals.

Purpose of the Study:

To review the conserved nature and modular structure of the TOR signaling network.
To discuss the role of TOR in regulating lifespan across different organisms.
To explore the implications of TOR pathway manipulation for human health and longevity.

Main Methods:

Literature review of research on TOR signaling network.
Analysis of conserved signaling modules and their functions.
Examination of studies linking TOR pathway to lifespan regulation in model organisms.

Main Results:

The TOR network comprises modular signaling components that sense diverse signals like nutrients and stress.
TOR pathway activity is conserved in its function to regulate lifespan in yeast, roundworms, flies, and mice.
Interventions targeting TOR signaling modules or activity demonstrably extend lifespan in model organisms.

Conclusions:

The conserved and modular TOR pathway is a key regulator of cellular processes and lifespan.
Modulating TOR activity presents a promising avenue for interventions aimed at improving human health and extending lifespan.