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Related Experiment Video

Updated: Jun 13, 2026

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

CD8+ Tregs in lupus, autoimmunity, and beyond.

Ravi K Dinesh¹, Brian J Skaggs, Antonio La Cava

¹Division of Rheumatology, Dept of Medicine at the David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-1670, USA.

Autoimmunity Reviews

|April 14, 2010

Summary

CD8(+) regulatory T cells (Tregs) show promise for treating autoimmune diseases like lupus. Inducing these cells with a specific peptide offers a potential new immunotherapy strategy for immune system disorders.

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Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

Isolation of Double Negative αβ T Cells from the Kidney

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Published on: May 16, 2014

Area of Science:

Immunology
Autoimmunity
T cell subsets

Background:

CD4(+)CD25(high) regulatory T cells (Tregs) are crucial for immune homeostasis.
Emerging evidence highlights immunoregulatory functions of CD8(+) T cells (CD8(+) Tregs).
Impaired Treg function is observed in autoimmune diseases, suggesting therapeutic potential.

Purpose of the Study:

To review the role and mechanisms of CD8(+) Tregs in autoimmunity.
To focus on the involvement of CD8(+) Tregs in lupus.
To explore therapeutic strategies involving CD8(+) Tregs.

Main Methods:

Induction of CD8(+) Tregs in autoimmune mouse models using a tolerogenic self-peptide.
Analysis of the phenotype, function, and role of induced CD8(+) Tregs.
Review of existing literature on CD8(+) Tregs in autoimmunity.

Main Results:

A strategy for inducing CD8(+) Tregs via tolerogenic self-peptides has been developed.
New insights into the characteristics and function of induced CD8(+) Tregs have been gained.
CD8(+) Tregs play a significant role in autoimmune conditions, particularly lupus.

Conclusions:

CD8(+) Tregs represent a promising target for immunotherapy in autoimmune diseases.
Targeting CD8(+) Tregs could lead to improved management of lupus and potentially other conditions.
Further research into CD8(+) Tregs may unlock new treatments for chronic infections and cancer.