[Nephrotoxicity of aminoglycosides. II. Preventive studies with oral administration of verapamil]

The effect was studied of oral verapamil administration in two different doses on gentamicin nephrotoxicity. Three groups of Wistar male rats were studied: 1) treated with gentamicin 100 mg/kg b.w. subcutaneously, 2) treated with gentamicin s.c. and verapamil 5 mg/100 ml given in drinking water, 3) treated with gentamicin s.c. and verapamil 20 mg/100 ml. The examinations were performed after 3, 7 and 10 days of gentamicin administration and after 10 days of gentamicin removal. Oral verapamil administration in these doses did not prevent the renal functional and histological damage after gentamicin administration. Renal cortex content of gentamicin was lower only after 3 days of gentamicin administration (statistically significantly) in the verapamil groups.