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Published on: March 14, 2014
Intravenous voriconazole after toxic oral administration
J W C Alffenaar1, S van Assen, J G R de Monchy
1University Medical Center Groningen, Department of Hospital and Clinical Pharmacy, RB Groningen, The Netherlands. j.w.c.alffenaar@apoth.umcg.nl
Abstract:
In a male patient with rhinocerebral invasive aspergillosis, prolonged high-dosage oral administration of voriconazole led to hepatotoxicity combined with a severe cutaneous reaction while intravenous administration in the same patient did not. High concentrations in the portal blood precipitate liver enzyme abnormalities, and therefore, oral administration of voriconazole may have a hepatotoxicity profile different from that of intravenous (i.v.) administration. Intravenously administered voriconazole might still be an option after oral-voriconazole-induced toxicity has resolved.
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