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Updated: Jun 13, 2026

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Published on: June 2, 2014
A visual migraine aura locus maps to 9q21-q22.
P Tikka-Kleemola1, V Artto, S Vepsäläinen
1Folkhälsan Research Center, Biomedicum Helsinki, PO Box 63, 00014 University of Helsinki, Finland. maija.wessman@helsinki.fi
Researchers identified a new genetic region on chromosome 9q21-q22 linked to visual migraine aura. This finding suggests shared genetic factors between migraine with aura and certain types of epilepsy.
Area of Science:
- Genetics
- Neurology
- Ophthalmology
Background:
- Migraine with visual aura, particularly scintillating scotoma, affects numerous individuals.
- Identifying genetic factors is crucial for understanding migraine pathophysiology.
Purpose of the Study:
- To pinpoint susceptibility loci for visual migraine aura in families with scintillating scotoma.
- To investigate the genetic underpinnings of visual aura in migraine.
Main Methods:
- Linkage analysis was performed on 36 Finnish multigenerational families (351 individuals).
- Microsatellite markers were used to analyze genetic linkage in individuals with and without visual aura.
- Promising loci were further fine-mapped using additional markers.
Main Results:
- A novel migraine aura locus was identified on chromosome 9q22-q31 (HLOD = 4.7).
- Fine-mapping revealed a shared 12 cM haplotype segment on 9q21-q22 among affected individuals.
- Linkage was also observed to loci on chromosomes 12p13, 5q13, 6q25, and 13q14.
Conclusions:
- A new locus for visual migraine aura is mapped to chromosome 9q21-q22.
- This region's prior association with occipitotemporal lobe epilepsy suggests shared genetic susceptibility between migraine and epilepsy.
- Susceptibility variants for visual aura in both conditions may reside in the 9q21-q22 locus.
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