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Breast density changes associated with postmenopausal hormone therapy: post hoc radiologist- and computer-based

Mads Nielsen1, Paola C Pettersen, Peter Alexandersen

  • 1Department of Computer Sciences, University of Copenhagen, Copenhagen, Denmark. madsn@nordicbioscience.com

Menopause (New York, N.Y.)
|April 14, 2010
PubMed
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Oral hormone therapy (HT) significantly increased breast density in postmenopausal women over two years. Computer-automated methods for assessing breast density show promise compared to traditional approaches.

Area of Science:

  • Endocrinology
  • Radiology
  • Gerontology

Background:

  • Hormone therapy (HT) is used by postmenopausal women.
  • Breast density changes are a concern with HT.
  • Assessing breast density traditionally involves radiologist interpretation.

Purpose of the Study:

  • To evaluate the effect of oral HT on breast density in postmenopausal women.
  • To compare computer-automated breast density assessment with traditional methods.

Main Methods:

  • A randomized, placebo-controlled trial involving postmenopausal women receiving oral estrogen and drospirenone for two years.
  • Breast density was assessed using radiologist-based methods (BI-RADS, interactive threshold) and a computer-based technique (radiograph heterogeneity).
  • Correlations between breast density changes and hormonal/bone metabolism markers were analyzed.

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Main Results:

  • Radiologist-assessed breast density significantly increased in the HT group compared to placebo.
  • Computer-based assessment showed no change in breast density in the HT group, unlike placebo.
  • Changes in mammographic markers correlated between radiologist and computer methods in the HT group.

Conclusions:

  • Two-year oral HT significantly increased breast density in postmenopausal women, with associated hormonal and bone density changes.
  • Computer-automated breast density assessment techniques may offer advantages over traditional methods.